Welcome to Historic Downtown Sikeston Get reacquainted with the heart of Sikeston, Missouri. Browse our directory of Partner Merchants or buy your tickets in advance for one of our great events! We’re so glad you’re here. Explore DOWNTOWN DIRECTORY restaurants From sweet to savory, from sunrise to late night, we’ve got what you need right here. SHOPPING Outfit your home, your registry, or yourself all in one neighborhood. SERVICES Financial advisors, realtors, insurance agents, artists – meet the experts who call Downtown Sikeston “home.” LEARN MORE LEARN MORE LEARN MORE COME VISIT Location 215 N. New Madrid St.Sikeston, MO 63801 Contact Us Phone : (573) 380-3801 Email: director@downtownsikeston.org Our Office Hours MON-FRI 08:00 – 4:00 Follow Us Facebook-f Instagram As a Main Street America Affiliate™, Historic Downtown Sikeston is part of a national network of more than 1,200 neighborhoods and communities who share both a commitment to creating high-quality places and to building stronger communities through preservation-based economic development.